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On a higher level, similarity between phylogenetic trees is related to protein interactions in large sets of interacting families [ 15- 22].
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Interestingly, all of these 20 sequences contained a 15 bp stretch sharing a high level similarity with E. coli ArcA-P binding consensus motif.
Additional File 8 summarizes these high level similarities.
Reducing high-level similarity may contribute to the plausibility of an analogy if what is eliminated is a preventive cause.
SubMap associates the subclasses between datasets by using a more abstract, higher-level similarity measure (i.e., the enrichment score of ranked subclass markers).
The approaches above focus on high-level similarities between networks without attempting to match individual nodes in the networks.
The Jaccard similarity index revealed a higher level of similarity between 12 h and 24 h groups than that between 3 h and 12 h groups.
In fact, the higher level of similarity found was between the groups "H" and "I" (50.35 %).
Clustering leaf traits separated well the species and hybrid entities, showing a higher level of similarity between R. ferrugineum and R. myrtifolium.
However, values of less than 2.0 suggest a higher level of similarity than evident from amino acid identities.
In comparison with the other AVRs, this region in AVR4 shares a higher level of similarity with avidin.
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