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Systems pharmacology models, in general, tend to span multiple timescales bridging detailed mechanism with higher level responses or functional outputs.
Accordingly, the recent UK National Clinical Guidelines recommend the use of formal validated structured assessment tools as part of the detailed clinical assessment process to help to classify PDOC status appropriately. 1 12 Serial observation over time is also recommended to identify any trajectory towards more consistent or higher level responses.
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They can be 'ground' focused only or may include the higher level response structures, and they can be simple (single agency) or complex (multi agency).
Spike-timing-dependent-plasticity (STDP) is used to make the system able to learn high level responses.
By contrast, agreement was poor between moderate and high level responses.
A C. difficile toxoid vaccine has been developed and induces high level responses of serum antitoxin A IgG in healthy volunteers [ 77].
While respondents seem to prefer the second highest response, there may be something different about satisfaction (manyi) in that respondents seem more likely to choose the highest level response, at least before 2007, when more than 20% selected the highest level), which we do not see in the ladder or happiness (xingfu) variables (Table 3).
It is a high level response".
"I think investors are looking for some very high-level responses to this condition," she said.
Thus, a positive coefficient indicates that increases in a particular predictor increase the changes of higher-level responses and a negative coefficient indicates that increases in the predictor decrease the chance of high-level responses.
Qualitatively, the data in Fig. 1 show that students' responses are not binary but show a gradually decreasing trend with taxonomic distance (i.e., a decreasing fraction of high-level responses and an increasing fraction of low-level responses).
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