The second group of genes contained many targets of PPAR α, a nuclear receptor transcription factor associated with the high-level regulation lipid metabolism (dark blue nodes).
This is true in both XEN and TS cells, suggesting either that other, as yet unidentified regulators must be involved and/or that tissue specificity is established after higher-level regulation of these factors (Additional file 2B).
Based on these TFs and membrane proteins, a signaling pathway is inferred that potentially explains the higher-level regulation of these TFs in the respective gene regulatory network.
Thus, individual regulation requirements may protect against depressive symptoms, but working in a unit with a generally higher level of regulation requirements does not seem to be protective.
A higher level of regulation could add to that".Which would be appropriate, I argued earlier, given the huge potential social costs of accidents at ultra-deep offshore wells.
The association between a higher level of regulation requirements at the individual level and a lower level of depressive symptoms concurs with the theoretical assumptions of ART.
A higher level of regulation of gene expression is represented by the seven sigma factors of C. glutamicum [ 14] that might exert their function in differential gene expression by the molecular mechanism of sigma factor competition [ 21, 22].
It is a term that refers to the various forms of supportive behaviours by which one learner can assist another peer to achieve higher levels of regulation (De Guerrero & Villamil, 2000).
Higher levels of regulation requirements are therefore considered a positive working condition and are expected to lead to better health.
Higher levels of regulation requirements were associated with lower depressive symptoms at the individual level (p=0.04), but not at the workplace level.
