In fact, it is also possible that this subgroup of patients with higher levels of sensitization would be more susceptible for developing widespread symptoms representing the 35 44% of sufferers with TTH presenting co-morbid fibromyalgia syndrome [27].
There was also a lack of reporting on pregnancies or transplantations, which has important implications since previous alloantigen exposure can induce high levels of sensitization.
These results combined gives support for the involvement of peripheral mechanisms in localized chronic myalgia, and may implicate that patients with chronic pain constantly have their immune system switched on with higher levels of inflammatory mediators leading to peripheral sensitization, which may drive central sensitization processes and pain [40].
The findings pointed to an association between organochlorine compounds and the higher levels of total IgE in newborns, signaling a higher allergic sensitization in the industrial region.
We could demonstrate that persistent sensitization, i.e. sensitization to the same allergens both at 4 and at 8 years was related to higher levels of that allergen at 8 years of age as compared with those with onset of sensitization between 4 and 8 years of age.
Other studies looking at endotoxin variations in non-farm environments, [ 56 ] have found that higher levels of endotoxin in house dust are associated with less allergen sensitization in infants aged 9 24 months, as measured by skin prick testing.
Consistent with a possible training-induced sensitization of PBMC to release IL-6, we found higher levels of IL-6 mRNA in the PBMCs of athletes than in untrained subjects, both in humans and horses.
These oils contain higher levels of irritating chemical compounds that could damage the skin, lungs or lead to sensitization.
