Sentence examples for higher level of constraint from inspiring English sources
Estimates of noncoding diversity did not differ significantly from those of synonymous diversity in either D. melanogaster or D. pseudoobscura (Wilcoxon signed-rank test; P = 0.31 and 0.36, respectively), which would seem in contrast with the higher level of constraint at intergenic regions than that at synonymous sites previously observed in D. melanogaster/D.
A larger historical N e for D. simulans than D. melanogaster predicts higher levels of constraint on synonymous and nonsynonymous sites in the former species.
This may simply reflect differences in the overall importance of proteins for cellular functions, with more important proteins showing both higher levels of constraint on their amino acid sequence and stronger selection for codon usage.
These observations are consistent with a high level of constraint of the sequence variation, caused by strong purifying selection.
First, it appears that vertebrate pol γs show a high level of constraint, with little sequence and structural variability within the group.
In contrast, TashHN shows a high level of constraint and may function to alter a property of the host leukocyte that is fundamental to infection by both T. annulata and T. parva.
The use of water from the river imposes an unusually high level of constraints on the design of the plant, due to possible extremes in temperature and the variable level of solids in suspension and other pollutants.
This difference is likely due to a higher level of functional constraint on the perigenic sequence [ 36] of lettuce.
A higher level of functional constraint on protein-coding exon sequences should lead to lower level of nonsynonymous variation which usually generates low average nonsynonymous:synonymous substitution ratios.
Considering the generally high degree of distance conservation of the IHR1s, their length might have been under a higher level of evolutionary constraint than the DNA sequences within the regions.
