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Success of cancer prodrugs relying on a foreign gene requires specific delivery of the gene to the cancer, and improvements such as higher level gene transfer and expression.
The highest risk of death from breast cancer was observed in patients with either top 10% or 25% higher level gene expression (P < 0.05, Additional file 5).
Moreover, recovered recombinant viruses with the nsp1 β mutations by reverse genetics induced higher level gene expression of type I IFNs than that of wild type viruses.
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Manner, J. et al. MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema.
Constitutive promoters that ensure sustained and high level gene expression are basic research tools that have a wide range of applications, including studies of human embryology and drug discovery in human embryonic stem cells (hESCs).
These terms were mapped to high level gene ontology categories with CateGOrizer [ 60], using the "Aqua" categorization.
Wickersham, I. R., Sullivan, H. A. & Seung, H. S. Production of glycoprotein-deleted rabies viruses for monosynaptic tracing and high-level gene expression in neurons.
Surprisingly, the β-globin locus control region (LCR), although critical for high-level gene expression, plays little role in the overall architecture of the active locus.
RNA virus vectors are attractive vaccine delivery agents capable of directing high-level gene expression without integration into host cell DNA.
High-level gene amplification events were less frequent than LOH or copy number gains.
Stable, long-term, polyclonal high-level gene marking was observed using relatively low multiplicities of infection (MOI s, and transgene expression was detected in all lineages.
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