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Enrichment of 2ROs in PI domains, as shown by PFAM analysis, also suggested higher interconnectedness of the post-2R network.
In particular, those who are located in the center of the network are less exposed to novelty and innovative behavior since their higher interconnectedness with homophilous pairs likely increases the risk to be influenced from colleagues [ 3].
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With the need to respond to and integrate a multitude of external and internal stimuli, plant signaling is highly complex, exhibiting signaling component redundancy and high interconnectedness between individual pathways.
Drugs with multiple targets are responsible for this high interconnectedness.
For the above situation (with β = 1) this implies ≈ a unsigned = 1 and ≈ a signed = 0. Thus, the two genes have high interconnectedness in an unsigned network but zero interconnectedness in a signed network.
The overall network contains 701 drug-target connections, in which 198 drugs (~78% of the total) and 165 targets (~80% of the total) compose the largest connected component of the network, reflecting high interconnectedness between the drugs and their targets.
On the other hand, high spatial interconnectedness promotes local biodiversity at the expense of local stability and supports communities with a wide range of interspecific interactions.
We examined the topology of the network with various reference genomes and noted that when more closely related bacteria were selected, the clusters became larger with a higher degree of interconnectedness when compared to clusters derived from more distantly related reference genomes (Table 1, 2, 3).
In recent reports on the bank, the agency has raised flags about the "vulnerabilities" of capital markets businesses, including "the confidence-sensitivity of customers and funding counterparties, risk management/governance challenges, and a high degree of interconnectedness and opacity".
"With a portfolio of €4.4tn euros in European Union's assets, and high and rising interconnectedness with the wider financial system, these insurers create a source of potential spillovers.
We also observed additional crosslinks that suggest a high degree of interconnectedness among SWR1's functional modules.
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