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A compound that exhibited more favorable kinetics and higher imaging contrast for H3Rs in the brain was considered as the best radioligand, and its utility in receptor occupancy studies was further demonstrated by PET in monkeys.
Since the nanoflowers displayed excellent scattering properties, they were used for dark-field imaging of cancer cells, showing higher imaging contrast than corresponding spherical AuNPs.
Although the imaging depth of OR-PAM is similar to that of pure optical microscopes, OR-PAM provides much higher imaging contrast for optically absorbing tissues [ 21].
The use of F ab′ 2 and Fab fragments of R1507 demonstrated that a higher imaging contrast can be achieved at earlier time points (Heskamp et al. 2012; Fleuren et al. 2013).
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Positron emission tomography (PET) is a non-invasive method that visualizes the locations and levels of radiotracer accumulation with high imaging contrast.
The core/shell nanoparticles shows high imaging contrast between the tumor and the adjacent tissues and controllable photothermal therapy (PTT) and chemotherapy.
Affibodies are a new class of engineered affinity proteins widely used in imaging, diagnostics and therapeutics, due to their improved properties, such as small size, robustness, high stability, and high imaging contrast compared to the best known affinity molecules (i.e., antibodies).
Achieving high concentrations of tracer in the tumor and low concentrations in other tissues results in high imaging contrast, which is crucial for imaging sensitivity.
Finally, A11 antibody showed highest microPET imaging contrast in two different xenograft models.
Advanced MRI techniques include endorectal MRI, high magnetic field scanning (3-Tesla), high resolution T2-weighted imaging, contrast enhanced MRI and diffusion-weighted imaging.
Both articles have comparable outcomes, which are improved simultaneous theranostic imaging contrast, high loading and delivery of DOX drug.
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