Without it, more frequent and higher dosing is often implemented, resulting in poorly controlled asthma.
Higher dosing regimens, especially in youngest children are suggested to achieve the prophylactic target range.
Similarly, we observed a negative preference for drug administration modes that involve higher dosing frequency albeit the magnitude of the effect was small and close to zero.
Hydraulic dosing rates fluctuated as expected with higher dosing rates during warm seasons with near zero or zero dosing rates during cold seasons.
Although an increase in cardiac output, glomerular filtration, and distribution volume would make the case for a higher dosing, the emergence of an acute renal failure exposes the patient to the risk of an overdosing [30].
The result showed significant increase in break thermal efficiency due to addition of silver nanoparticle in Biodiesel, where higher dosing level of AgNPs further improved the performance of the engine.
To this day, the FDA has not asked Purdue to change its recommendations regarding higher dosing, despite the fact that a recent examination of medical records in Ontario, Canada concluded that one in 32 patients on high doses of the drug fatally overdosed.
These levels of reduced susceptibility to oseltamivir are of uncertain clinical significance, but may require higher dosing of oseltamivir [15].
[7], [8] The elevated plasma concentrations found in our study reflect in part the higher dosing used in our patients.
Therefore, had we not observed symptoms of toxicity in rabbit model, higher dosing would have been possible, with potentially even more dramatic changes in vascular morphology.
