Sentence examples for higher dose response from inspiring English sources

Finally, we observed that letrozole consistently sensitized cells to addition of AEW541, as reflected in higher dose response index values for AEW541.

Alternatively, this high dose response of maximal neutrophilic influx may be responsible for the phenomenon.

Eventually, this resolves such that significantly fewer cells give the high dose response.

Similar activity was observed in the assessment of pharmacodynamic biomarkers of erlotinib activity that showed a high dose response relationship because of the inhibition of pEGFR, cell proliferation measured by inhibition of BrdU uptake, and apoptosis (annexin V labeling).

At low doses a weak immune response of IgM anti-idiotype was detectable and at higher doses responses were lower or undetectable.

This suggests that for some environmental chemicals, especially those with hormonal action, low-dose effects need to be examined rather than relying on traditional high-dose response effects.

Similarly, low- versus high-dose responses triggering different signaling pathways could also sum to an overall nonmonotonic curve.

Hormesis is a binary response phenomenon with low-dose stimulation (or inhibition) of effects by substances producing opposite high-dose responses.

The benchmark dose (BMD) method provides additional information regarding its uncertainty but high quality dose response curves are required in order to provide estimated BMDs with small confidence intervals [ 10].

The maximum response to radiation exposure was observed at dose 2 Gy (~3-fold) with higher doses, the response diminished to 1.5-fold, as depicted in Fig. 3.

The high dose cytolethal response appears non-specific occurring in all cell lines with every steroid tested.