For all drugs adverse events are likely to be dose related, with higher event rates at higher doses.
There are no data to indicate whether benefits are dose related but higher doses are more likely to provoke dangerous hyperkalemia (The RALES Investigators 1996).
The findings indicated the relationship between birth weight and pollution was dose related - the higher the exposure, the lower the average birth weight.
We can speculate that the effect of PEEP is dose related and a higher PEEP level (>12 cmayO) may further increase the IAP in critically ill patients.
Two studies [ 16, 42] observed a dose related response with high risk ratio of stillbirth in mothers who smoke ≥10 cig/day compared to 1-9 cig/dandand those who smoke ≥1 pack/day in contrast to <1 pack/day respectively.
The harms it can cause are immediate and dose related, the risks being highest for Homeric (uncontrollable) laughter.
Arthropathy in animals appears to be dose related, with increased risk in higher doses and after longer duration of treatment.
A dose related effect was observed for gestodene, desogestrel, and levonorgestrel, with higher doses being associated with higher thrombosis risk.
When we looked at the plasma concentration of genistein for the CD-1 mouse and F344 and S-D rats, we found a much higher dose-related response of genistein concentration in the plasma of S-D rats compared with CD-1 mice and F344 rats.
Also MESC significantly (p < 0.05) showed dose related stimulation of humoral immunity and a highest percentage leucocyte mobilization of 10.15% at 250 mg/kg dose.
A dose related effect of ethinylestradiol was observed for gestodene, desogestrel, and levonorgestrel, with higher doses being associated with higher thrombosis risk.
