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The markers that showed higher discordance were eliminated.
This state is confirmed in our study with a higher discordance among elderly.
Studies employing IHC have generally found higher discordance rates than those employing in situ hybridization, suggesting methodological issues may play a role in apparent discordance.
This is consistent with previous reports noting higher discordance between local HER2 testing and central HER2 testing relative to discordance among central laboratories [ 12, 18, 19].
This greater difficulty in correctly mapping reads with indels to the reference genome may have resulted in the higher discordance rate observed between the two-paired samples.
The latter higher discordance rate between conventionally classified luminal and BluePrint Luminal patients might be related to the variability in IHC ER and/or PR assessment at local institutions.
Similar(51)
The results of the three procedures were compared and showed a concordance rate of 83.8%; higher discordances were observed in 0 or 1+ immunostaining cases, which showed high-level amplification (15.4%) and HER-2 transcript overexpression (20%).
The trend towards longer survival in the discordant group as well as the absence of these high discordance rate in patients with rare mutations of V600 (Richtig et al, 2012) would hint to the latter explanation.
Our study was designed to produce high concordance on nonreligious stimuli (e.g., "Eagles really exist") and high discordance on religious stimuli (e.g., "Angels really exist").
A high discordance rate was found between the QTF test and the TST (Table 3).
The cause of high discordance between NT and biopsy was attributed according to the respective risk factors of failure.
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