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On the other hand, five cases showed the accumulation of LOH from low to higher differentiated portions.
Thus, endomitosis results in higher differentiated cells that are capable of producing more platelets than a cell of lower ploidy 23.
Accumulation of allelic losses from high to lower differentiated portions was found in seven cases and accumulation of allelic losses from low to higher differentiated portions was found in five cases.
Focally, there may be expression of K1/K10 (particularly in higher differentiated tumor cells which can end in the formation of horn pearls), and to a lesser extent K4 and K13.
Patients with CD44+ tumors (defined by dichotomization at intensity >weak or by >26% positive cells), presented significantly more often with larger, higher differentiated tumors, but no significant differences were observed in tumor localization (tonsil or tongue base), stage, or age between patients with CD44+ and CD44− tumors (data not shown).
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To exclude mixed, non-SQCLC tumor compositions, the highest differentiated sections in the tumors were selected for IHC analysis and DNA extraction.
By the degree of cell differentiation HCC are divided on high-differentiated, moderately differentiated, low- and undifferentiated types.
Responsiveness to caffeine, which acts on muscle-specific ryanodine receptor channels, was significantly higher in differentiated CM-derived iPS cells than in differentiated CF-derived iPS cells.
Consistent with protein expression results, βIII-tubulin and Map2 mRNA levels were higher in differentiated neurons than in neural progenitors, but lower in cells differentiated in the presence of LPA or S1P as compared with control-differentiated cells.
Additionally, by specialising in a particular stage of production, these firms develop focused innovational capabilities that further increase their competitive advantage in offering higher quality differentiated services.
Moreover, staffing in the U.S. is a $150B industry consisting of profitable companies looking to move up the value chain with higher margin, differentiated products.
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