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Compared with ExomePeak, which treated each bin independently, HEPeak was shown to achieve higher detection specificity and sensitivity in the simulated data.
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High detection specificity relies on the design of specific probes and the elimination of nonspecific binding on the sensing surface.
As a result, utilizing the newly-proposed immunosensor, the HIgG can be detected down to 0.5 ng/mL, and the high detection specificity is offered.
This Bi2S3-based photoelectrochemical sensor possessed excellent photoelectron property and presented high detection specificity, even distinguishing single-base mismatched sequences.
Gray-scale inversion and choice display sessions resulted in significantly higher nodule detection specificity and decreased sensitivity compared to traditional display.
The gyrB target was chosen for the detection of P. aeruginosa rather than the commonly used ecfX target, because of its slightly higher detection rate and specificity on clinical isolates [25 27].
The receiver operating characteristics (ROC) curve of the peak calling results is shown in Figure 4A and we can see that the ROC curve of HEPeak wraps around that of ExomePeak, which indicates that HEPeak achieves a higher detection sensitivity and specificity.
Nanospray MS Poisson detection focuses on efficient ionization, reduced surface losses, high operational duty cycle, detection specificity through two MS selection stages, and a probabilistic algorithm for pattern recognition.
To achieve high detection sensitivity and specificity, target-specific DNA amplification instead of whole genome random amplification was used prior to microarray analysis.
The main advantages are the high detection rate and specificity and improved heterozygote detection.
This multiple antibody-immobilized dendrimer platform along with high detection sensitivity and specificity paves the way for potential use of this system as a diagnostic and prognostic tool for monitoring cancer progress and responses to therapies of metastatic cancer patients.
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