Sentence examples for higher density chips from inspiring English sources

Limitations of this study include the relatively low array density of the 56 K chip we used compared to current commonly used higher density chips.

As new higher density chips are developed, re-genotyping previously genotyped samples or new samples with new chips or whole genome sequencing is expensive.

Transition to higher density chips will require including multiple marker sets in one analysis because breeders will not re-genotype most animals.

For example, long-range LD probably explains why predictions based on 50 K single nucleotide polymorphism (SNP) markers have similar accuracies as predictions based on higher density chips (800 K) for within-breed prediction of Holstein cattle [ 9, 10].

When genomic predictions are performed using data from SNP chips with different densities, genotypes of SNPs absent from low-density chips are usually inferred (imputed) from the higher density chips.

When constructing a reference population for imputation to higher density chips or platforms (e.g. whole-genome sequence), the policy to include the closest ancestors will contribute to a decrease in imputation errors.

Due to higher LD, convergence of SNP effects could become even lower for a higher density chip, although the convergence of DGV should remain unchanged.

These qualifications make it a potential, new means for routine analysis and a complementing method for microarrays and high density chips.

Many other studies reporting performance results from findhap.f90 applied the program with the main purpose of imputing genotypes from low to high density chips [ 15, 35, 36].

The overall success of using high density chips to interrogate common variants for common disease is a matter of debate [ 2]; however, it is unarguable that many unexpected signals for disease have been identified and replicated in multiple studies, even if their biological implications still remain a mystery in most cases.

They are rather used to illustrate the magnitude of accuracy expected when imputation is applied to move from low to high density chips, which also indicates a strong dependency of the performance of findhap.f90 on the number of unambiguously imputed loci.