The PDMS networks formed from concentrated solution had a relatively higher effective interconnectivity of the network chains and a higher degree of constraints of fluctuations of the network junctions than did the networks formed from more dilute solutions.
The chicken STAT site is perfectly conserved with mammalian STAT sites; the IRE-like element, while less conserved, retains some of the features of mammalian IREs, including the TAAT motifs which display the highest degree of constraint in mammals (Figure 3).
In particular, by selecting conditions for disordered lattices that yield a high degree of constraint density fluctuations (described below), the MFA becomes most susceptible to error.
The H3K4me2/3 nucleosome occurs at the 5' end of actively expressed genes and displays a high degree of constraint and phasing characteristics of its positioning, with bulk nucleosomes showing a much lower degree of reproducibility in positioning [ 35].
2. The plus-one nucleosome in activated oocytes exhibits the highest degree of constraint on the apparent rotational positioning, indicated by the most dramatic approximately 10-nt periodic oscillation of the activated oocyte DNA ends at this region.
Furthermore, the 5'-end precision and homogeneity of mature miRNAs show a high degree of evolutionary constraint.
The first nucleosome downstream of the transcription start site (conventionally referred to as the plus-one nucleosome) often exhibits the highest degree of positional constraint.
Interestingly, PBD1 is the only conserved region in the F1 sub-domain, with 15 of 21 identical or highly conserved amino acids, indicating a high degree of evolutionary constraint and functional conservation.
The decrease in molecular weight observed is due to a high degree of polypeptide constraint imposed by a large number of intrachain disulfide bridges formed in the non-reduced THP molecule [ 34].
Also, it is becoming apparent that each insect possesses a distinct complement of highly divergent nAChR subunits whose sequences do not reflect a high degree of evolutionary constraint and thus may play diverse roles in different species.
