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As expected under selection for secondary structures, paired sites experience higher constraint than unpaired sites, i.e. significantly lower numbers of conserved optimal codons and consistently lower numbers of synonymous substitutions.
We find significant differences between the selective constraints acting on enzyme-coding genes from different cellular compartments, with the nucleus showing higher constraint than genes from either the cytoplasm or the mitochondria.
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Using a comprehensive number of mammalian taxa and extended statistical analyses, we have found that, in general, interacting mtDNA-encoded residues, alike interacting nDNA-encoded residues, are subjected to higher constraints than their corresponding noninteracting counterparts.
Comparison has revealed that concrete-filled tubular joints with PBR have much higher constraint capability than joints without PBR.
A main effect of constraint level was also found, F 1, 174) = 8.3, p <.01, partial η =.045, with longer RTs for the high-constraint than for the low-constraint condition.
Therefore, long windows put a higher constraint on the error than on the model order, which indirectly emphasizes model accuracy.
If there is selection for secondary structures, one may expect higher constraint at structurally important (paired) than at structurally less important (unpaired) sites.
The current study supports these conclusions and further suggests that, in addition to being highly conserved, splicing signals within introns have been subjected to proportionately higher selective constraint than intergenic regions within the human population.
Odom and colleagues have previously shown that the transcription factor binding regions that were retained between multiple species had higher sequence constraint than species specific binding regions [ 24], however the interdependence between conservation of the region around the bound site and the retention of the consensus site was not addressed.
A more parsimonious explanation would be an HT event to the ancestor of these two species; however, the lower divergence found for BuT2 is inconsistent with this hypothesis, unless BuT2 is under a higher selective constraint than Adh gene in these species, which is unlikely.
The FNK PS type is 20 mm at the height of the post and 16.8 mm at jumping distance, which offers higher constraints between post-cam mechanisms than other regular PS prostheses and allows the range of ± 2° for varus-valgus constraint, ± 2° at extension position, and ± 5° at flexion position for internal-external rotation constraint.
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