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For one immunogen, the neutralizing response was increased with a higher breadth compared to the Wild-Type.
Expression breadth, however, shows a contrasting pattern, i.e. longer genes have higher breadth of expression, possibly to ensure those structural features associated with gene plasticity.
Similar results were found in LTNPs, although we observed a higher breadth and a trend towards a higher magnitude of HIV-1-specific CD8+ T-cell responses which were mainly driven by strong anti-Gag responses.
Alongside the higher breadth, the increased magnitude of responses found in LTNPs by ELISpot assay was confirmed by ICS analysis, although not reaching statistical significance, when we determined the percentage of IFN-γ-, TNF-α and IL-2-producing CD8+ T-cells following stimulation with specific peptides (Figure 3A).
Representative examples of these responses are shown in Figure 2A and B. In line with the ELISpot data, we found a higher breadth of responses in LTNPs by ICS analysis with LTTS and LTNPs subjects targeting a median of 2 (range 1 5) and 5 (range 1 9) epitopes, respectively (P = 0.001).
The species pool of >40y showed significantly higher values (P < 0.05) of Δ+ and Λ+, indicating a higher breadth and heterogeneity of taxonomic structure.
Similar(53)
These patterns form "cascades" with different profiles: for instance, a fast-spreading rumor that's quickly snuffed out would have high breadth but little depth, and low virality.
The 3D menu was preferred by users at high breadth levels, and the 2D menu showed better performance than the 3D menu with low memory load.
Table 2 Wild Card assessment main (concise) results from the expert survey Wild Card Impact * = Low ** = Medium *** = High Breadth of effect Main Vulnerability Importance for decision makers Main weak signals Aviation Road Rail 1 1.
As we can see, the triangle is essentially consisting of problems inherent in any double bottom line or hybrid entity: how to balance the need for high breadth of outreach and economic profitability with the need to reach the most vulnerable and have an impact in getting them out of poverty by helping them develop their enterprises.
Namely, there is a strong depletion not only of "high rate/low breadth", but "high rate/medium to medium-high breadth" categories of sites and proteins.
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