Sentence examples for higher brain uptake from inspiring English sources

N1QC demonstrated higher brain uptake and remarkable mitochondrial localization post cerebral ischemia reperfusion.

Thus, the studies confirmed enhanced bioavailability, higher brain uptake, retention, and delayed clearance with curcumin cocrystal micellar nanocarriers.

Before treatment with tariquidar, Mdr1a/1b dKO mice showed higher brain uptake than WT mice throughout the entire PET scan (Figure 1).

We observed significantly higher brain uptake in baseline WT mice compared to S1R-KO mice at all time points during 60 min PET scan (P < 0.05).

As a weak P-gp substrate and under normal physiological conditions, 11C]phenytoin is expected to have higher brain uptake than that of a strong substrate.

Meta-substituted phenylalanine prodrugs displayed 10-fold higher affinity for LAT1 and 2-fold higher brain uptake than parasubstituted analogues.

Both radiotracers showed high brain uptake and σ2 receptor binding specificity in mice.

One of the synthesized compounds, [11C]CW4, showed high brain uptake in rats and further evaluated in non-human primate (NHP) using PET-MR imaging.

High brain uptake (0.8% ID/g) at 1 min was observed, followed by gradual radioactivity clearance from the brain for 5 60 min after the injection of [14C]7m6CP into rats.

Ex vivo autoradiography and initial biodistribution studies in rodents were performed, suggesting that [18F]12b was able to penetrate the blood-brain barrier (BBB) with high brain uptake (0.71% ID/g at 60 min post-injection) and no defluorination was observed.

All three ligand leads demonstrated fast kinetics and high brain uptake.