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Higher aberrations (astigmatism for example) could be corrected by introducing an appropriate optical element between the telescope and the eye.
Increasing slightly the beam separation in the pupil comes at the cost of higher aberrations that might distort the beam overlap.
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The exception to this is donor 8 who had slightly higher aberration frequencies than donor 24, in spite of the fact that donor 24 showed ARS symptoms, whereas donor 8 did not.
However, in typical eyes the highest numerical aperture at the largest pupil diameter also implies the highest aberrations and the worst point spread function [ 6].
Other chromosomes with high aberrations counts were chromosomes 1, 2, 9 and 11 with 37, 38, 34 and 32 alterations respectively.
Each sample has very high aberration rate with focal and large scale CNAs, typical of this tumour type.
More importantly, genes from each gene set with high aberration frequencies among corresponding subgroups indeed show significantly distinct patterns among the 9 subgroups (Fig. 4).
Analysis of the 7 of the donors with the highest aberration frequencies was repeated 16 months postirradiation and is also shown in Table 2. Chromosome aberrations were observed in 13 individuals 3 months after the accident.
A second round of sampling was conducted about 16 months after the accident for 7 of the donors showing the highest aberration frequencies in the first round of sampling.
DSAEK has gained increasing popularity as it induces less post-operative astigmatism, less high order aberrations, and encounters higher patient satisfaction, when compared to PK [ 4].
It is possible that higher order aberrations contribute to this non-uniform intensity, even though we did not find the mouse eye higher order aberrations to be significantly larger than that of the human eye.
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