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Further investigation, including high-quality trials with standardised radiological and clinical outcome measures for young patients, is warranted to clarify treatment approaches and safety.
Recent large high-quality trials have questioned the clinical effectiveness of medical expulsive therapy using tamsulosin for ureteral stones.
Clazosentan, magnesium, and simvastatin have been tested in large high-quality trials but failed to show a beneficial effect.
Upper tract urothelial carcinoma (UTUC) is a clinically heterogeneous disease that lacks high-quality trials that provide definitive prognostic markers.
Indeed, national courts in Serbia, Croatia and Bosnia have conducted scores of high-quality trials of lower-ranking defendants accused of war crimes.
Significant reductions in SBP and DBP were only observed in the low-dose green tea polyphenols, the long-term duration, parallel-design RCTs, high-quality trials subgroups or when the confounding effect of caffeine was removed.
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Details related to the dropouts were reported in all high quality trials.
We performed a sensitivity analysis on various other meaningful trial subsets of all high quality trials.
The Authors highlighted also the weak support by high quality trials (Smith et al. 2012).
While there have been many trials done with acupuncture, most of them are small pilot studies and large scale high quality trials are rare.
However, most recent evidence revealed, when high quality trials were analysed, that the benefits of PTH on mortality and neurological outcome were lost(3).
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