Metamorphic chronology confirms high-grade conditions (540 505 Ma) persisted beyond isostatic adjustment of the high-P/low-T orogenic margins.
Protracted high-grade conditions produced significant partial melt, which facilitated gravity driven southward extrusion involving internal ductile flow processes.
Granulite facies metamorphism in the high-grade orogen core, which formed the upper plate to the deeper thrust wedges occurred at significantly lower pressures (4.3 6.0 kb), higher T/depth ratios (≥ 38 47 °C/km) and low ∆ P/∆ T clockwise P-T paths indicating only moderate burial and protracted high-grade conditions.
In addition to its role in low-grade inflammatory cardiometabolic conditions, emerging evidence is suggesting that the gut microbiota can influence the risk of high-grade autoimmune inflammatory conditions such as type 1 diabetes mellitus, coeliac disease, inflammatory bowel disease and rheumatoid arthritis, the incidence of which has risen dramatically since the 1940s.
Could increases in cIMT, in conditions with high-grade inflammation such as RA, simply reflect current (but quickly reversible) inflammation of the vessel wall rather than more permanent structural vessel changes?
Pelitic rocks at higher structural levels (low- to medium-grade zone) underwent prograde metamorphism to middle amphibolite facies whereas rocks at deeper structural levels (high-grade zone) attained upper amphibolite facies conditions.
To understand how rehydration reactions proceed in natural systems, assess the role of geofluid infiltration in rehydration metamorphism, and check the validity of our model, we simulated rehydration of a high-grade greenschist rock under greenschist-facies conditions.
We found that naive human ESCs converted under our optimized conditions contributed to high-grade teratomas containing tissues representing all three germ layers, regardless of the presence of FGF and Activin A in the medium.
So call the condition something else, perhaps "high-grade dysplasia".
Dysplasia, in particular high-grade dysplasia, is regarded as a preneoplastic condition (Rosai et al, 1992).
