This brings us a small step closer to the prospect of global, high-volume studies in critical care.
The checklist of Behrens and Langer turned out to be a suitable tool of quality appraisal for the high volume of studies.
In the High Volume on Intensive Care IVOIREE) study, septic study patients were randomised to high- volume haemofiltration (70 ml/kg/hour for 96 hours) or to standard-dose CVVH (35 ml/kg/hour).
In a subgroup analysis of the ARDSnet low versus high tidal volume study, it was noted that older survivors recovered from respiratory failure and achieved spontaneous breathing at the same rate as younger patients, but had greater difficulty achieving liberation from the ventilator and successful ICU discharge [ 10].
Companies have made similar vaccines at high volume, and animal studies have shown that Ebola virus is fairly easy to defeat with the proper immune response.
Survival of patients on low versus high volume hemofiltration was studied (9/31 vs 6/21, P = NS).
One such study, known as the IVOIRE (High Volume in Intensive Care) study, which compares 70 mL/kg per hour versus 35 mL/kg per hour, is currently ongoing in Europe.
The authors addressed the issue of surgeon experience by doing a sensitivity analysis based on high volume (> 50 pre-study cases) versus low volume (< 50 pre-study cases) operators, and found no significant difference in outcomes.
The IVOIRE (hIgh VOlume in Intensive caRE) study [160] enrolled 140 AKI patients with septic shock from 18 ICUs in Europe and compared the efficacy of HVHF (70 ml/kg/h) with standard-volume hemofiltration (35 ml/kg/h).
The multicenter "IVOIRE study" (hIgh Volume in Intensive care), which compared hemofiltration doses of 35 ml/kg/h versus 70 ml/kg/h in patients with sepsis-induced shock, AKI, and multiple organ failure, may settle this debate in the near future.
In the IVOIRE (hIgh VOlume in Intensive caRE) study [ 12], patients with severe infection and acute kidney injury (AKI) were treated with CRRT and randomly assigned to hemofiltration rates of 35 mL/kg/h or 70mL/kg/hh.
