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However, the subsequent injection should be cancelled in nearly half of patients due to a too high trough, without renal function impairment.
In Table 7 we present the "High" trough doses of the three immunosuppressives that are used to treat organ transplant rejection in eukaryotes.
In patients with high trough serum infliximab levels, better clinical responses were attained.
High trough levels are counter-intuitive in light of the relatively high target binding affinities of most IgG1 mAb therapies.
Tobramycin toxicity is associated with high prolonged serum concentrations [ 14, 15] and especially high trough concentrations [ 16].
High trough infliximab concentrations measured at the end of treatment initiation (that is, before the fourth infusion) seem to predict infliximab maintenance in both RA and SpA.
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This explains the high trough-to-peak ratio of the antihypertensive effect and reduced variability of BP with once-daily administration.
(See "Is China Hoarding Copper?" and " China Can't Stop Copper's Softening").. "Higher trough commodity prices drive higher trough earnings," said Goldman Sachs analyst Jerry Revich, who expects mining equipment companies' earnings to decline by 55.0% peak to trough compared with a fall of more than 80.0% for other machinery companies.
Healthy subjects have a deep trough, with the pelvis back tilted with respect to the start upright position; on the contrary FAI patients show a higher trough, thus preserving a forward tilted pelvis.
My favorite sight gag involved a head-high trough of flowing water that miraculously stops just as our log passes, sparing riders a deluge guaranteed to soak them to the skin.
The highest trough level was 86 μg/ml (58 122).
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