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However, these chelates cause low sensitivity and, thus, requiring a high tissue concentration of the contrast agent to be effective for MR imaging.
In addition, we assigned the earthworm metabolite HEFS to this group: the very high tissue concentration of HEFS implies it has some kind of structural or stabilising role.
When hormones containing gel was applied directly on breast skin, a high tissue concentration of E2 and the highest PI were obtained [ 35].
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Marine mammals from such regions, moreover, show high tissue concentrations of organochlorine (OC) xenobiotics2,3, increasing their susceptibility to other anthropogenic stressors.
The gorgonian Plexaura homomalla is a favored diet of C. gibbosum [26], [27], [45], despite having high tissue concentrations of deterrent cyclopentenone prostaglandins.
Furthermore, very high tissue concentrations of CEA were demonstrated in MCT.
High tissue concentrations of respirable CD accumulate in the human lung in coal miners.
Photosensitiser photodegradation at low photosensitiser doses, and light attenuation by high tissue concentrations of A1SPc account for these findings.
This suggests high tissue concentrations of vancomycin in particular are important in its efficacy as a prophylactic agent.
Some of these effects seem to be concentration dependent as high tissue concentrations can induce both cell necrosis and apoptosis (Balkwill, 2002).
Goldstein and colleagues found that amikacin nebulization, using an ultrasonic device, achieved high tissue concentrations in piglets, far above the MIC of most Gram-negative strains [ 5].
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