Given increasing concerns over barriers to translating discoveries from the laboratory to the clinic or community, such high-throughput informatics methods are very desirable, and in our opinion, central to the P4 paradigm [4, 7 10].
What my colleague and research partner, Dr Alex MacKenzie, and I were trying to do in this paper is describe an approach by which one could use a high-throughput informatics pipeline to generate hypotheses about drugs currently approved for other disorders that might also be effective for a rare disease, the so-called 'drug repurposing'.
Recent advances in high throughput genotyping and bio-informatics provide unprecedented opportunities to unravel the genetic basis of clinical normal tissue radiosensitivity.
In the context of medical imaging we call this high-throughput imaging informatics". The science is complicated and occasionally arcane to the outsider so Miller repeatedly references important innovators in other fields to illustrate his intents.
There is significant investment in high cost, high throughput technologies, trained laboratory work force, and laboratory informatics to achieve the level of validation required by CLIA or CAP to offer the test for patient-care.
Furthermore, the growing avalanche of high throughput experimentation data has created both an opportunity, and a major modeling and informatics challenge, for material design and discovery.
A novel approach for design of experiments (DOE) is outlined that combines high throughput multiscale modeling, sensitivity analysis, and information extraction from massive computational data using informatics tools.
Unfortunately these primary sources are diluted by providers of large scale high throughput screening data, who prime their customers to expect a certain degree of noise, and the potentially poor state of the informatics component is just one of the many failure modes for experiments that are designed to use quantity to compensate for lack of quality.
Faster speed with high throughput.
