Measurement of barrier properties by OECTs is a rapid, and potentially low-cost method and thus represents real future potential as a new technology for high-throughput dynamic monitoring of live-cell toxicology.
Particularly, exploring the relationship between high throughput technology and dynamic behavior on metabolic pathways directly associated with human diseases will thus constitute a mayor research target in future.
Here, high throughput profiling interrogates dynamic gene expression profiles that offer a depth of resolution unmatched by traditional biomarker panels.
Results show that selecting stable route leads to a higher throughput in dynamic network topologies.
The resulting solution is a flexible and powerful system for performing dynamic high throughput automatic microscopy.
While some details of this chip and process have been previously described [10], [11], more details on the design, function and characterization of the dynamic array chip are in preparation (Unger M, et al. The Dynamic Array: High Throughput Real-Time Quantitative PCR by Microfluidic Large Scale Integration, manuscript in preparation, 2008).
MRM-MS is of high sensitivity, high specificity, wide dynamic range, high throughput, and low background and has been widely applied for the accurate quantifications of multiple proteins simultaneously, including low-abundance proteins in complex biological samples.
These include quantification of metabolites, unequivocal identification of metabolites, provision of longitudinal (time-resolved) dynamic datasets, high throughput (for example, 500 samples a week, with 200 metabolites for each sample), implementation of quality measures [ 18- 21] and standardized reporting [ 22].
If large scale monoliths could be made to be reproducible and operationally stable, they could also offer an alternative mode of operation that could provide high throughputs and high dynamic adsorptive capacities.
An alternative chromatographic system could be comprised of a long column packed with large particles which have fractal pores (fractal particles) that have high pore connectivities and which allow high intraparticle diffusional and convective flow mass transfer rates providing high throughputs and high dynamic adsorptive capacities.
