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To study the role of cell-extracellular matrix (ECM) interactions, microscale approaches provide the potential to perform high throughput assessment of the effect of the ECM microenvironment on cellular function and phenotype.
Our innovative approach toward evaluation of BMD using optimized image acquisition and novel image processing techniques in preclinical models of RA enables high throughput assessment of anti-rheumatic agents offering a powerful tool for drug discovery.
High throughput assessment of epigenetic signatures on a genome wide level is so far available for methylation analyses.
The large numbers of hits from computation searches then require high throughput assessment using chemical libraries and assays for the specific targets.
Microarrays are designed for high throughput assessment of relative mRNA levels, but comparative expression measurements are constrained by limits in the dynamic range of detection [ 6].
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Mullokandov, G. et al. High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries.
Herein we report on the use of micro-CT imaging as a method to perform high-throughput assessment of fetal skeletons.
A rapid and high-throughput assessment of brain penetration is important in the 'hits to lead' and 'lead optimization' phases of the drug discovery process.
Specifically, Bio-COBRA is a high-throughput assessment of DNA methylation of large sample sets, very quickly and quantitatively.
It allows high-throughput assessment of basic safety, pharmacokinetics and target specificity of the compound of interest before clinical testing.
Furthermore, technological advances have made high-throughput assessment affordable, providing a means of feasible and sensitive detection.
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