Similarly, the performance characteristics of the new strategies appeared to be as good as those of the existing search strategies except for the sensitivity (53.4%) of the new high-specificity strategy.
Based on the above analysis, except for the sensitivity of the new high specificity search strategy being lower than that of the existing search strategy, the performance characteristics of the new strategies derived using the 15 randomly sampled journals appeared to be as good as those of the existing search strategies.
When comparing the high specificity search strategies, the specificity of the new strategy was 1.3% higher than that of the existing search strategy (98.8% versus 97.5%, p-value < 0.001); the sensitivity (47.1%, 95%CI43.9%to to 50.3%), however, was much lower than that of the existing strategy (93.1%, 95%CI91.5%to to 94.8%); the precision and accuracy did not differ statistically.
Except for the sensitivities of the high specificity search strategies, the other performance characteristics of the new strategies developed using both the random sampling and top journal approaches were close to those of the existing search strategies (Table 3).
The 2 new strategies seemed to work well except for the sensitivities from the high specificity search strategies.
Tables 1, 2, 3 contain the overall percentages (or means) for each of the traditional and novel stroke risk factors that were considered, as well as the percentages (or means) among participants without strokes, and with strokes based on the high sensitivity and high specificity case-identification strategy.
The proposed strategy exhibits high specificity in discriminating cognate miRNAs, and the dual signal transduction process enables the detection of miRNA concentrations as low as 7.3 fM.
On the other hand, strategies with high specificity will correctly identify those who should not be offered diagnostic tests and preventive interventions, but will overlook some individuals at high risk who could benefit from these interventions.
