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In high specificity model, a TEII recognizes and hydrolyzes only aberrant residues, while in low specificity model, a TEII hydrolyzes with low rate both correct extender units and incorrect residues.
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Table I in appendix 1 shows predictive statistics fixing low false positive rates of 25%, 10%, and 5% (high specificities) for model 2 at 28 weeks.
We observed that the majority of the plant specific tools may be made to predict targets with a high specificity in the model organism, A. thaliana if the parameters of predictions are optimized.
On the other hand, the high specificity yielded by the model signifies that the selected functional domains are meaningful since they do not exist in most of the non-toxin proteins.
This 3-tiered stratification method retained both the high specificity of the 2-year model and the high sensitivity of the 4-year model.
A covariance model with high specificity assigns low bit scores to all sequences that do not belong to the model family.
Fifteen of these drugs (88%) also did not prolong the QT interval in an animal model (Table 2), which indicates that the animal models have high specificity.
This model has high specificity and flexibility in controlling the extent of pancreatic severity, which makes it suitable for studying extrapancreatic organ damage, but the precise mechanism is not fully understood.
Such a low prevalence of potential exposure generally suggests use of a model with high specificity to minimize false negatives in epidemiological risk calculations (Nuckols et al. 2004b; Stewart and Correa-Villasenor 1991).
With our simulations study using synthetic data generated by a toy model, we showed that until high amount of experimental noise in the data, cross validation SPCA prediction error can work as a threshold to invalidate a too simple kinetic model with high specificity and sensitivity.
FT had similar and high specificity and sensitivity for both models (sum 1.81 and 1.86).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com