The potential risk for bird to human transmission - even if could not be quantified - during HPAI outbreaks among wild birds justifies early follow-up of exposed persons by means of serological testing using high-specificity assays.
In conclusion, anti-NF155 antibodies measured by high-specificity assays defined a distinct subset of CIDP patients presenting with younger onset age, tremor, extremely high CSF protein levels, symmetric spinal root and plexus hypertrophy, and marked prolongation of distal and F-wave latencies, and therefore might be a biomarker for a unique subset of CIDP.
A recently developed assay system, that uses tandem mass spectrometry, has been reported to have extremely high specificity for steroid assays and might be considered for a future assay system [ 30, 31].
Furthermore, the high specificity of molecular assays allows the specific detection of B. pseudomallei even if closely related bacteria, such as Burkholderia thailandensis, Burkholderia vietnamiensis, Burkholderia cepacia, and other Burkholderia and Ralstonia species, are present in the same environment (16 – 16).
The no-template controls gave non-detectable signals in all samples, confirming the high specificity of the assays.
While immunologic tests have almost unlimited throughput, the high specificity of these assays may result in failure to identify etiologic agents with different antigenic determinants.
Pulldown by a control antibody (anti-HA) showed very low non-specific level of fluorescence, thereby demonstrating the high specificity of SiMPull assay.
In addition, for the orfX-LAMP assay, high specificity was acquired when this assay was subjected to 116 reference strains, without any false positive amplification for non-MRSA strains (Table 1).
Sera from 25 healthy individuals tested negative indicating the high specificity of the assay.
High specificity of the assay was verified with seven other bacterial strains.
None of five ASFV-related viruses tested produced a positive signal, demonstrating the high specificity of the assay.
