Consider for instance the 841 paralogous pairs for which the presence/absence expression profile of each paralog was identical in the medium and high paralog specificity analyses (Fig. 3).
A recent development aiding a diagnosis of IPA is an assay for the detection of serum Aspergillus galactomannan (GM), a polysaccharide produced by the fungal cell wall during growth that illustrates moderate sensitivity and high specificity in pooled analyses [ 20].
As for the second part of the analysis, the methods for taxonomic classification are mostly conservative as they show a high proportion of true negatives, low numbers of true positives and high specificity scores for all the analyses.
Previous meta-analyses have found high specificity but low and highly variable estimates of sensitivity.
Stratified analyses consistently showed a high specificity across different sample types and methylation methods (include both primer sequences and location).
High specificity is very important in genome wide analyses where the numbers of predictions can be very large and false positives must be minimized.
A high specificity was essential for the nature of downstream analyses applied in this study.
Miniaturized immunosensors, that combine the analytical power of microfluidic devices with the high specificity of biomolecules, have been intensively studied for clinical analyses, environmental immunoassays and biochemical studies.
Genome-wide expression analyses have shown that amiRNAs have similarly high specificity as endogenous miRNAs [21], [27].
Given these concerns regarding the expected specificity of this measure, and the importance of high specificity when evaluating rare exposures (Dosemeci and Stewart 1996), further analyses of this measure were judged as unlikely to be informative and thus not performed.
The results of these tissue expression analyses have demonstrated that this microarray has high specificity and sensitivity, and will be a useful tool for chicken functional genomics.
