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This model demonstrated a robust performance in the discovery (AUC = 0.952) and verification (AUC = 0.980) phase with a high separation power independent from gender.
With the progressing complexity of the samples to be analysed, the quest for chromatographic systems with high separation power is increasingly relevant.
The high separation power of small molecules is based on a doubled separation, primary the chromatographic by MCC and secondary by differences in drift time in the IMS.
Because most lattice points are colored, a high separation power is apparent for DegPenta), with no information concerning species during the BLSOM calculation.
GC-MS combines high separation power with good identification capabilities, while reporter gene assays allow the measurement of the hormonal potency of samples [ 31, 32], as they are based on the activation of the nuclear estrogen hormone receptor [ 33].
However, the versatility and high separation power of liquid chromatography (LC—as HPLC or UPLC) when coupled to tandem mass spectrometry (LC MS/MS) have been proven to be an excellent analytical platform for mediator lipidomic assays with detection limits in the picogram range [32 37].
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In general, the RP-Amide column provided the highest separation power with different mobile phases.
The area under the curve of the classifier was 97.3%, and demonstrated the high, significant separation power of the classifier.
It is shown that the latter strategy gives the highest potential for increasing the separation power of the devices.
For the high probability thresholds, we define the "separation power" of a feature as.
Although our analysis shows that the scoring model possesses good separation power, it cannot avoid generating some high-scored false-positive links.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com