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The sub-matrix weight ({mathbf {T}}_{um}^h) is the only difference in Eq. (13) with the original WMF, which may lead to high running time.
The PF algorithm (as described in the next section in detail) has a high running time due to the resampling step - according to the complete cumulative distribution; therefore, an adequate parallel implementation would fetch a remarkable speed-up.
Moreover, the Multi-Layer Perceptron method [ 34] has been tested, however it required a very high running time, not providing the demanded output even after hours of computation.
Although many RNA molecules contain pseudoknots, computational prediction of pseudoknotted RNA structure is still in its infancy due to high running time and space consumption implied by the dynamic programming formulations of the problem.
Unfortunately, even the most efficient algorithm by Reeder and Giegerich (R&G) still has a high running time of O(n), although it strongly restricts the class of predictable pseudoknots.
Such algorithms enjoy several strength-points: uniform nodes distribution, symmetry, flexibility, simplicity, strong theoretical foundations, but suffer from some drawbacks: high running time (equivalent to O(V )) and poor local minima.
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Note that during the winter the heat pumps have the highest running time, providing heat to the apartments, which limits their response.
According to the authors, increasing ℓ would improve results, although it will come at a cost of a higher running time.
Since our algorithm considers many more possible secondary structures in comparison to alternative methods, our program has a higher running time.
More sensitive than heuristic methods for searching biological databases, the Smith Waterman algorithm is widely used but has the drawback of a high quadratic running time.
However, the utilisation of a radioisotope (RI), high running costs and long testing time prevent the MIBG scan from becoming a routine clinical examination.
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