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Although the finding is interesting, further trials are required because all trials possessed one high risk component of bias and two trials had an additional four unclear risks.
Again, risk of bias was high for all trials, with two high risk components for one trial 43 and one high risk component for the two other trials.
39 48 Although the finding is interesting, further trials are required since one trial possessed one high risk component of bias, and the other possessed two.
26 High (1) Unclear (6) One high risk component: 6 No primary outcome measure specified No primary endpoint specified No ITT reported High (1) Unclear (3) Low (2) N/A (1) One high risk component: 6 Design problematic with comparison to a previous non-randomised group.
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Although reasons for the high risk components provided concern for potential bias, results from meta-analyses evaluated critically within this context enabled an overview of the evidence to be presented, strength of effect to be presented, and tentative conclusions to be proposed to advance research.
Under this approach, a sample that is in the high-risk component for any variable is high risk overall.
Christensen et al 13 had one high-risk component owing to poor reporting affording a lack of clarity across all components, no primary outcome being pre-specified, no primary end point being pre-specified and no intention-to-treat analysis reported.
The concept of risk-based maintenance was developed to inspect the high-risk components usually with greater frequency and thoroughness and to maintain in a greater manner, to achieve tolerable risk criteria.
The ultimate aim of this activity is the definition, on the basis of this assessment, of a list of preventive or mitigating actions (such as relocation, shielding or preventive maintenance) for the most high-risk components.
Guidelines recommending imaging of patients with high-risk components and symptomatic patients have been published, but they do not give suggestions on appropriate intervals for imaging (MHRA 2012, FDA 2013).
The first phase develops self-assessment guides that can be used by clinicians and health care organizations to evaluate certain high-risk components of their EHR-enabled clinical work systems.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com