Note that we are affecting the quality of only a small part on the periphery, of the higher resolution tiles in the view, during a given smoothing process.
Give it a few seconds to download the higher resolution tiles when you stop moving the view.
An example illustration of horizontal smoothing between two tiles (a high-resolution tile H and a medium-resolution tile M on right) is given in Figure 5. Algorithm 1: Example horizontal smoothing function.
(B ) The nc82 pattern of the high-resolution tile image is non-rigidly aligned to that of the standard brain.
In this way the high-resolution tile image is globally aligned to the standard brain and corresponding target volume in the standard brain is identified.
Finally, a non-linear transformation was applied to locally register the high-resolution tile image to the JFRC2013 standard brain using a symmetric diffeomorphic registration algorithm (Avants et al., 2008) with a combination of mutual information and normalized cross correlation as the similarity metric in the local alignment.
This is possible as the high-resolution tiles cover relatively small portions of the genome.
In practice, IGV uses a hybrid approach; combining precomputed lower-level zoom levels with high-resolution tiles computed on the fly.
On the rest of the tissue area, the Definiens algorithm 'chessboard segmentation' strategy is applied to analyze tissue regions at high resolution (10×) tile by tile.
The fourth article "Quality of Experience for large ultra-high-resolution tiled displays with synchronization mismatch", by S. Deshpande and S. Daly, studies the quality of visual experience for large ultra high-resolution displays made from individual display tiles.
We then aligned the high-resolution image tile to the low-resolution whole brain image, using the reference nc82 channel, by means of image stitching (Yu and Peng, 2011), which obtains translations through searching the maximum normalized cross correlation using the fast Fourier transform (FFT).
