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High resolution sequence stratigraphic.
As noted above, visual display of syntenic mapping for several strains may facilitate detection of a new insertion as a new contig break (Fig. 4) and, if so, one can then use CoGe's tool GEvo for high resolution sequence comparison of the region in multiple strains to determine precisely where the insertion has occurred, although not what has caused it.
These findings suggest that centric fusions may involve different sequences in different genomes, and determining the precise mechanism involved requires high resolution sequence analysis.
To confirm cell line identity and exclude possible culture contamination, all cell lines used in this study were typed for HLA class I which cross referenced to previous high resolution sequence based typing of NCI-60 [ 20] or other cell lines.
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This new system allows simultaneous, high resolution sequencing of 152 identity informative markers (including 27 autosomal STRs, 7 X-chromosomal, 24 Y-chromosomal haplotype markers and 94 SNPs) plus 56 ancestry and 22 phenotypic informative SNPs.
With the advent of high resolution sequencing technologies there has been increasing interest in the study of genome-wide epigenetic modification patterns that govern the underlying gene expression events of a particular cell or tissue type.
HLA typing was performed by high resolution sequence-specific oligotyping after DNA amplification (PCR-SSOP) of 100 breast cancer Mexican mestizo patients and 99 matched healthy controls.
Tumours were detected using T2-weighted high resolution sequences.
With the advance of high resolution sequencing technology, several studies applied histone marker binding sites with ChIP-Seq data to identify promoters [ 17].
High resolution (sequencing) gels of the scission products by Hin-N54C-FeBABE and Fis-N98C-FeBABE are shown in Figures 5B,C.
Here, we report high resolution sequencing of 343 (322 unique) recent Alu insertion events, along with their respective target site duplications, precise genomic breakpoint coordinates, subfamily assignment, percent divergence, and estimated A-rich tail lengths.
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