In search of other organ involvement, a high resolution CT of the lungs, lungs function tests and cardiac MRI were done, all of which were normal.
We excluded patients with significant interstitial lung disease (ILD) defined based on extensive disease (> 20% lung involvement) on high-resolution CT lung (HRCT), or evidence of fibrosis on HRCT together with forced vital capacity (FVC) < 70% predicted and/or an FVC to diffusing capacity of carbon monoxide (DLCO) ratio < 1.6 in whom PAH was deemed secondary to lung disease [ 14].
Their clinical characteristics, lung high resolution computed tomography (HRCT) findings and pulmonary function tests were reported.
There are only a few specific indications for non-contrast CT in childhood, which include acute brain trauma, suspected renal calculus disease, lung high resolution CT (HRCT) for suspected pulmonary interstitial disease, perhaps paranasal sinus imaging and for some skeletal pathologies[ 13 15].
Further investigations are at the discretion of the treating physician and typically include lung function tests, ventilation/perfusion lung scans, high resolution CT and CT pulmonary angiography, and right heart catheterisation, if available (figure 3).
Firstly, we train the 3D CNN model with data in different resolutions and find out that models trained by high resolution input data achieve better lung nodule proposals generation performances especially for nodules in too small sizes, while consumes much more memory at the same time.
A standard high resolution reconstruction algorithm for the lung was employed.
High resolution CT scan of the lung showed diffuse bilateral upper lobe alveolar infiltrates.
We also excluded patients with pattern consistent with interstitial lung disease (ILD) (i.e. subpleural opacities, parenchymal bands, thickened interlobular septae, an irregular pleural interface, honeycomb lung) in high resolution computed tomography, as those patients were prone to develop PH secondary to chronic respiratory disease.
An abdominal MRI showed a 4 cm wide lesion of colon and a 3 cm wide lesion in perisplenic peritoneum; abdominal, celiac, para-hepatic and para-aortic enlarged lymph nodes of 1-2 cm of diameter, peritoneal and pleural effusion, while a chest high resolution CT scan showed multiple lung consolidations.
