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With high resolution, array CGH is capable of identifying the underlying chromosomal cause of ASD in a much greater number of patients.
This study compared t-AML to p-AML using high resolution array CGH in order to find copy number abnormalities (CNA) at a higher resolution than conventional cytogenetics.
T (brachyury) gene duplication has been recently identified as a major susceptibility factor in familial chordoma by linkage analysis, high resolution array comparative genomic hybridization (CGH), and quantitative real-time polymerase chain reaction (PCR) [10].
High resolution array CGH enables the detection of small CNVs involving one gene or part of a gene.
Additional investigations such as high resolution array CGH will be required to better understand those complex rearrangements.
The first function we discuss is the ability to view a single high resolution array CGH profile at multiple magnification levels.
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High resolution array-based comparative genomic hybridization (aCGH) is being used to profile CNAs of ever larger tumor collections, and better computational methods for processing these data sets and identifying potential driver CNAs are needed.
Our rationale was to reassess the mutation frequency of NF2, especially when combined with very high resolution array-CGH analysis of these tumors.
In summary, high resolution array-based CGH revealed large number of chromosomal aberrations previously identified in osteosarcoma by chromosomal CGH and conventional cytogenetic methods.
The 1q12/2p junction in CH1 cells was then mapped by high resolution array-CGH and FISH (Fig 1C and Fig S1 of the Supporting Information).
Frozen tissues from 114 breast cancers were analyzed using high-resolution array comparative genomic hybridization.
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