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Similarly, according to the model, a high resistance potential in nutrient scarce environments would be detrimental to growth and, if combined with a high growth potential, have no impact on the within-host pathogen load in the short term.
Whereas the model predicts that high growth combined with low resistance potentials are preferable for growth at the earlier stages of infection (Figure 4D & E), low growth combined with high resistance potential appears to be the optimal strategy for achieved growth over the long-term (Figure 4F).
P2: Adrenocortical responses to environmental perturbations are down-regulated in individuals with high resistance potential.
If ceftazidime, a 'high resistance potential' P. aeruginosa antibiotic, is combined with a 'low resistance potential' antibiotic, for example, amikacin, the high resistance potential of ceftazidime is not diminished/eliminated.
The principal drawbacks of miltefosine are its teratogenicity, prolonged treatment regimen, and high resistance potential which limits its usefulness in national elimination programs (4).
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Double drug therapy does not decrease resistance if a 'high resistance potential' antibiotic is used in the combination.
For example, in environments with high nutrient availability, selection for low severity and short duration of infection would be equivalent to selecting for high genetic resistance potential, ρ, with no selection pressure acting on the genetic growth potential (Figure 3A C).
In contrast, if nutrients are scarce, selection for low severity and short duration of infection would still favour animals with high genetic resistance potential ρ, but would simultaneously imply selection for low GP as only animals with low GP allocate the required amount of resources towards immunity (Figure 3D F).
Periodic high frequency resistance potential-current scans during the 500 h fuel cell test and post-test analysis of the membrane indicated no resistance increase of the plates and only trace levels of metal ion contamination.
The allocation rule adopted here indirectly implies host genetic influence on the distribution of resources, as a host with higher growth potentials but similar resistance potential relative to another host will allocate a higher proportion of resources towards growth than the immune response under the same pathogen challenge.
The main features of PDAC aggressive biological phenotype, early local invasion with high metastatic potential and a high resistance to radiation and chemotherapy (Yeo et al, 2002)–suggest the involvement of cells with stem cell characteristics in PDAC.
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