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The "High" release rate is 1.11 × 10−7 m3/s for 15 days, the same as the case in the Sect.
The drawback of this injectable chitosan solution is its relatively high initial burst release and high release rate for water soluble drug agents such as vancomycin hydrochloride (Ruel-Gariépy et al. 2000; Gavini et al. 2005).
Nevertheless, control using the high release rate in fall exceeded 90% in both crops, with no differences between rates in pepper, although the high rate was significantly better in tomato.
From a biological response perspective, high release rate of TNF- α indicates overproduction of proinflammatory cytokines related to overwhelming proinflammation; low release rate of TNF- α leads to failure to recruit a sufficient amount of neutrophils related to infection clearance.
This finding infers either a high release rate of TNF- α (r t 2max is above 6265.00) or a low release rate of TNF- α (r t 2max is below 5495.64), thereby inducing generation of unstable equilibria in the neutrophil immune response model.
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Under high release rates, fractures acted as the predominant flow pathways, with limited fracture matrix interaction.
Based on this contribution, it is now possible to simultaneously provide high release rates and long release durations, thus overcoming a fundamental limitation in drug delivery.
The lutein-loaded NLCs had high release rates of the drug in simulated intestinal fluid compared to simulated gastric fluid using modified Franz diffusion cells.
At low-release rates, liposomes are cleared from circulation before drug can be released, and at very high release rates, it behaves like free drug.
In vivo, however, these high release rates may be lower since only one side of the implant contacts the brain surface.
Even though not very high in our case, in general, hydrophilic polymers in the formulations result in a high initial burst and high release rates when PLGA with relatively high glycolide content (50/50) is used [ 28].
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