Exact(15)
Due to the segmented nature of its genome and a high rate of mutations during replication, seasonal IVs show an annual change of antigenic qualities in the HA and NA genes, requiring annual immunization.
Deoxyribonucleic acid analysis and multiple sequence alignment suggest that both P proteins may maintain their structural function in the ribosomal stalk, in spite of the high rate of mutations detected.
The HCV genome is widely heterogeneous, and replication errors cause a high rate of mutations [6].
This may be a viral strategy, where the low specificity of the virus polymerase generates frequent mismatches and a high rate of mutations.
The high rate of mutations found in the Maori families probably reflects the criteria used for selection of the families.
Another possible explanation for the high rate of mutations observed in the apicoplast is the polyploidy of the plastid genome.
Similar(45)
These RNA viruses, which include influenza and H.I.V. as well as SARS, have a high rate of mutation.
The high rate of mutation in the viral proteome provides it with the ability to survive in a variety of host species.
However, there are still obstacles in using RNAi as an antiviral therapy, particularly for hepatitis C virus (HCV) that displays a high rate of mutation.
Manifold special characteristics such as unavailability of introns, maternal inheritance, high rate of mutation, nonattendance of recombination possibility are demonstrated by mitochondrial DNA (Irwin et al. 1991; Pesole et al. 1999).
mtDNA is unique from the nuclear genome in so much as it is solely maternally inherited (non-mendelian patterning), and shows a relatively high rate of mutation due to the absence of error checking capacity.
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