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Using these approaches, model parameters can be well fitted to measured time courses provided from either experiment (in vivo) or simulation (in silico), i.e. high quality fits with minimal residual values can be obtained by global optimization methods.
As described in 'Separating probes of processes I–IV' below high quality fits of the combined CEST/CPMG data using this approach could be obtained for residues reporting on process II but not I.
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A high quality fit between unknown and standard reactions is the basis for identifying reaction constants that include on rate (ka), off rate (kd), and a calculated equilibrium dissociation constant (KD).
The physical environment is essential for staff and patient satisfaction.[ 5] IPC's physical infrastructure is a high quality, fit-for-purpose environment that includes 11 consulting rooms, five minor operation/procedure bays, and a large waiting area with 3 inter-linking sections to allow efficient work-flow across the multi-disciplinary team.
Good results with high-quality fits were obtained from both 7 and 0.5 mg·ml−1 samples, and these are shown in Figures 7(c) and 7 d).
Indeed, given the wide range of effects that the various perturbations exert on the cells' transcription factor expression, we were somewhat surprised that we were able to obtain high-quality fits with such a simple model.
We confirm that the same model also produces a high-quality fit to the separation between larger defects observed in MD simulations.
But what we think makes the A6 duo irresistible rather than merely competitive is the excellent high-quality fit and finish, with some of the slickest interiors we've ever seen on any cars.
WiserAdvisor.com is designed to ensure a high-quality fit for both clients and advisors.
Nevertheless, the model including leaf temperature responses of the gs × VPDL interaction was warranted, given the extremely high-quality fit of the model prediction of the independent datasets and, therefore, validated the approach.
Such models do not assume symmetry and it has been shown that any function with less than five parameters is unlikely to have the flexibility necessary to produce a high-quality fit to asymmetric sigmoidal dose-response data [ 22].
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