Sentence examples for high proportion of mutations from inspiring English sources

The observed fluctuations in heteroplasmy levels could be due to the different reprogramming states of the cell lines, i.e., highly pluripotent iPSCs predominantly produce energy by anaerobic glycolysis and carry a high proportion of mutations, even above the pathogenic threshold level.

Nonetheless, we and others have shown that mucinous tumors have a high proportion of mutations in RAS pathway genes and aberration of CDKN2A (p16) [ 1, 2].

CRCs with the microsatellite instability (MSI) phenotype have a defective mismatch repair system, which results in a high proportion of mutations in nucleotide repeats (microsatellites) throughout the genome.

The best understood were the two binding sites for C3d on SCR-19/20 SCR-19/20ach donein [ 84, 85], which may acconnt for theachgh proportion of mutations in SCR-19/20.

In contrast, in Drosophila melanogaster, only 18% of the genome is composed of TEs, but a high proportion of mutations (more than 50%) is attributable to their transposition [ 4].

Alteration of p53 by various mechanisms is a frequent finding in malignant disease, although the frequency of mutation in the gene varies considerably between tumour types, with a high proportion of mutations in lung cancer, lower gastrointestinal cancers and glial brain tumours, but low reported frequencies in melanoma and sarcomas (Soussi and Wiman, 2007).

The high proportion of mutation-negative cases that were displaying an oncogenic signature gave rise to the possibility that the signature could have some predictive value in the response to cetuximab beyond the mutation status.

Patients with the mental illness, which affects about one in every 100 people, had a higher proportion of mutations known as copy number variations in the genes involved with exciting or inhibiting the synapses between brain cells, the researchers report.

In addition, the observation of a higher proportion of mutations associated with CD8+ T-cell pressure, including reversions, in HIV compared to HCV highlights key differences in the strength of selection pressures on these two viruses, that is their plasticity and ultimately their ability to escape CD8+ T-cell responses.

Second, in large populations, a higher proportion of mutations are expected to be effectively selected because a higher proportion are expected to have N e s ≫ 1.

HSV-2 6757, although not 6757PR, conferred a slightly higher proportion of mutations in non-HSV DNA in the plasmid assay, than wild type HSV-1 and HSV-2, consistent with a mutator phenotype.