The significantly high proportion of nucleotide changes in the loop regions suggests that the secondary hairpin structure of GC42 is of functional importance.
In particular, we observed a relatively high proportion of morphological changes during biofilm formation by P. lipolytica; in these cultures, the smooth and opaque wild-type cells generated colonies with wrinkled or translucent morphologies (Fig. 1i).
A high proportion of women changed medication once pregnant.
In contrast, between-species nucleotide changes showed high proportion of non-synonymous changes for ATPase in the branches of bonobos, chimps and gorillas, but were less frequent in humans (cf. last clusters of Figure 3A and 3B).
The higher rate of change can also be attributed to the high proportion of non-synonymous changes seen in this case (5/9; Figure 1), which may be related to the immunological status of this child.
A high proportion of DNA methylation changes, even those in gene regions expected to exert an effect on transcription, were unassociated with changes in gene expression.
The high proportion of patients requiring changes to their treatment regimen, based on both drug resistance and adverse events, suggests that close monitoring and frequent assessment of sputum culture and drug resistance where patients remain or become sputum culture-positive during treatment is essential.
Composed of arkosic sandstone, which contains a high proportion of feldspar, the rock changes colour according to the position of the Sun; it is most visually striking at sunset, when it is coloured a fiery orange-red by the Sun's rays.
The few studies that have been carried out to understand the dietary habits of patients with CVD noted that a high proportion of patients is unable to change their dietary habits.
A relatively high proportion of studies found evidence of evolutionary changes, but clear evidence that adaptive evolutionary shifts were directly caused by climate change was somewhat less common [but see: (Franks et al. 2007; Thompson et al. 2007; Franks 2011; Avolio et al. 2013; Avolio and Smith 2013; Sultan et al. 2013; Thompson et al. 2013)].
