Human stem cells have a high proliferation rate and are therefore an abundant cellular resource.
These effects may have produced a reduced status that was associated with a high proliferation rate in experimental tumors.
For instance, the high proliferation rate of solid tumors cause some of the tumor cells to become progressively distant from vasculature and they soon encounter an environment deficient in oxygen.
MTT assay demonstrated the viability and high proliferation rate of L929 mouse fibroblast cells on the collagen type I-modified composite scaffold.
In biopharmaceutical manufacturing a high proliferation rate of production cell lines was long considered desirable since improved process yields often resulted from an increase in cell number.
SP cells from these tumors displayed an unexpectedly high proliferation rate which was selectively inhibited by Hedgehog and Notch blockade compared with conventional chemotherapies.
The tumour part that is classified as liver and/or vertebrae indicates areas with a high proliferation rate (B).
High proliferation rate must be met with reciprocally high apoptosis rate for maintenance of normal cellular homeostasis.
Moreover, we have shown that these cells display high proliferation rate and that they are capable of forming cluster spheres.
A high proliferation rate has been associated with enrichment paradigms that specifically included physical exercise adding a wheel in the cage for voluntary running [50].
In particular, CD133+ cells possess stem-like features, such as differentiation ability, high proliferation rate, sphere cluster formation and the ability to propagate tumour in permissive hosts.
