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Recent data from randomised treatment trials support a high progression rate in the long term [ 17].
The high progression rate is due to the study design (exclusion of radically treated patients and patients with no progression but incomplete follow-up).
Our results showed that single-agent D was inadequate in this setting; an unexpectedly high progression rate led to an early chemotherapy termination rate of as high as 40%.
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Superinfection with hepatitis D is associated with higher progression rate to chronic disease and to serious complications [3], [2] and may result in suppression of HBV replication, such that an individual with dual infection transmits HBV less than an individual infected only with HBV [4], [5].
A higher progression rate in adolescent females than males suggests that sex hormones may have influence IS curve progression.
The other study supported these findings, describing a significantly higher progression rate for oral dysplasia to OSCC in p16 hypermethylated cases (43.8% versus 17.4%; OR = 3.7) [ 28].
The model incorporated the results of a prior predictive value study [ 8] assuming a higher progression rate to TB disease in QFT-positive than in TST-positive subjects.
In addition, there was a significantly higher progression rate for those patients with Ta/T1 disease whose tumours demonstrated cytoplasmic cyclin D1 staining.
However, patients with pT1G3 were considered as muscle invasive tumours as they are recognised to have a significantly higher progression rate (Manoharan and Soloway, 2005).
Because patients with lack of progression during the pre-randomisation period will be excluded from our study, we expect to select for a higher progression rate in our study population.
This lower survival was due to a higher number of deaths occurred in chronic phase, reasonably unrelated to IM therapy or toxicity, and not to a higher progression rate in older patients.
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