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The use of combined T3/T4 was re-explored following a small but high profile study of thyroid cancer patients who were swapped from suppressive levothyroxine therapy, to a lesser dose of combined T3/T4[6]].
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These high profile studies - and others - prompted the UK's environment ministry (Defra) to investigate.
Several recent high profile studies have examined the processes constraining the metastatic growth of tumor cells in fruit fly models.
Several high profile studies support this hypothesis in which sham procedures involving only superficial anaesthesia were compared to the more invasive true procedure.
Recent high profile studies have found that maintaining the DNA methylation profile is necessary for maintaining long-term memory, because reduction (blockage) of global DNA methylation leads to long-term memory loss (Feng et al., 2010; Miller et al., 2010).
34 35 It is unclear whether this results from a generally improved publication rate or from the specific mix of indications and studies in our sample (mainly anticancer drugs with a few high profile studies for each drug).
High profile studies suggest that the benefits from improved utilisation can be enormous, and these studies include ones that attempt to put a value on the health gain that results from research [ 41, 42].
Indeed, some high profile studies have restricted their analysis of TF binding sites to the minority of sites located in the vicinity of genes that change expression following external stimulation or TF knock-down (Garber et al, 2012).
While some high profile studies have reported no difference between treatment and sham procedures, we found a positive though modest overall effect size (Cohen's d) from the invasive procedures included in the analysis.
Although some research supports these findings [ 40], high profile studies like the NDHS [ 4] and the Maternal Mortality and Morbidity study in 2008 [ 41] may be misleading in their indication that family support is not a major barrier to institutional delivery.
This notion may have been enforced by high profile studies which designate estimated GFR < 15 ml/min/1.73 m without dialysis as being "untreated" "kidney failure" [ 19], although recent initiatives by KDIGO have attempted to distinguish between stage 5 requring dialysis versus stage 5 disease not requiring dialysis [ 20].
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