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"In the last few years, our small institute [now with 17 principal investigators] is publishing at least one-third of all high profile papers in the biological sciences from China".
The importance of stochastic events and molecular chaperones in the relationship between alleles and phenotypes has been called to attention in two recent high profile papers (Burga et al., 2011; Casanueva et al., 2012).
Along the way, the authors correct findings published in several high profile papers by others and provide a refreshing interpretation of the nature of the lipid accumulation in glp-1 mutants and the role of SKN-1 in response to this lipid overload.
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This paper is a response to a critique of the author's previous high profile paper in Nature [ 1].
However, there was a high profile paper from the McMahon lab, published two years ago in Cell, claiming that if all three epsin genes were knocked down by siRNA in HeLa, BSC1, or RPE1 cells, clathrin-mediated endocytosis was effectively abolished: the phenotype was as severe as when clathrin or AP-2 were knocked down.
Other journals that had carried subsequent high-profile papers from Dr Potti behaved in similar ways.
Science alone has recently retracted high-profile papers reporting cloned human embryos, links between littering and violence, and the genetic profiles of centenarians.
"We will capture high-profile papers too, but what the focus is [on] is not using surrogates, not using the Nature reviewing process to judge your own work," Nurse says, adding that with a senior management team including winners of the prestigious Louis-Jeantet Prize and a veritable gaggle of fellows of the Royal Society to sniff out good research: "We have pretty good noses".
"We published a couple of high-profile papers in Cell and Nature Genetics where I was first author," he says.
"An industrial postdoc implies that you'll stay in industry, because it's harder to publish high-profile papers.
Recent high-profile papers have concluded that radiologists can detect but not localise abnormalities in briefly presented mammograms (Evans et al., 2013, 2016).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com