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In cases of a high potential benefit we may sometimes even be permitted to act supererogatorily rather than do our duty (Kamm 1985).
Third, virtually all agricultural research directed at overcoming the effects of heat, drought, and associated biotic and a biotic stresses will be of high potential benefit to ameliorating the potential negative effects of global warming.
Such "smart algorithms" do appear to prevent nocturnal hypoglycemia (21), suggesting that "this is a treatment we could use right now … [with] very low risk and very high potential benefit … [that] could eliminate 80% of hypoglycemia overnight".
Controversially, the ACMG recommended that genetic identification of the 24 conditions be sought and reported "without reference to patient preferences" both because of the high potential benefit to patients and because individual informed consent seemed logistically unfeasible.
20 However, although people with prediabetes are at high risk for diabetes and evidence points to high potential benefit from lifestyle interventions, 21 diabetes prevention requires societal change and a concerted global public health approach.
1 3 While multiple risk factors for lower birthweight and birth complications have been identified, 4 their predictive power remains modest, 5 and there is therefore high potential benefit in identifying novel risk factors for birth complications.
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Since there are currently no cures or highly effective treatments for HD, there is a high potential benefit-to-risk ratio for these studies.
While biologics and bioengineered strategies are widely considered to represent the high potential benefits for those who have sustained a spinal injury, few such therapies have been thoroughly tested with appreciable efficacy for use in human SCI.
It requires an investment around 100 €/m2 and, in most scenarios, produces high potential benefits in terms of primary energy savings (42 ÷ 44 kWh/m2a), polluting emission reductions (11.5 ÷ 12.0 kgCO2-eq/m2a) and global cost savings (5 ÷ 78 €/m2).
Priority setting provides a rational process for allocating health research funding, because the available funds are low in comparison to the very high potential benefits [ 13].
In seasonal breeders, SSI has the highest potential benefit when committed during the mating season and only if victimized females rapidly re-enter oestrus.
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